Abstract: The ecological environment is relatively weak due to the low precipitation and high evaporation. The study area is the Dananhu mining area of Hami coal field,which is located in the Turpan-Hami basin. For the ecologically vulnerable area,the authors studied the hydro-geological conditions for water-preserved mining and its feasibility. The structure of aquiclude in the roof of major coal seam has been systematically assessed. Furthermore,the authors investi- gated the development characteristics of the height of the water flowing fractured zone,and studied the development po- tential of aquifer under protection. Then,the practical application for water-preserved mining had successfully conduc- ted at the 1801 working face of Dananhu No. 5 Coalmine as a case study. This study proposed a preliminary program for the development and utilization of protecting high salinity aquifer water, gaining experience for water-preserved mining in the ecologically vulnerable area of the Turpan-Hami Basin. This paper first put forward and practiced the roof water disaster control and water-preserved mining combining engineering in the typical ecological fragile area of Tuha Basin,providing theoretical and practical references for safely exploit the coal resources in Turpan-Hami coal field,which is one of the four major coal bases in Xinjiang Province.