Abstract: With the substantial increase in the level of comprehensive mining mechanization in coal mines, the problem of high-concentration dust in the workplace has seriously threatened the safety of coal mine production and the health of workers. Therefore, it is very important to control the dust mass concentration within the allowable range. As an effective dust removal treatment method, high-frequency standing wave agglomeration technology has great potential and practical application value. In order to study the influence of high-frequency standing wave parameters on the agglomeration efficiency of respirable dust particles, firstly, the motion law of respirable dust particles is simulated by COMSOL Multiphysics multi-physics simulation software, and then the respirable dust particle agglomeration experiment is carried out through the experimental platform. The simulation results show that when the sound pressure level increases from 140 dB to 155 dB, the distance from respirable dust particles to the node position is shortened from 49 cm to 1.4 cm. At 155 dB, the movement distance between respirable dust particles is the smallest, and the distribution of respirable dust particles near 100 μm large particles becomes denser, and the collision probability may be higher. When the frequency increases from 40 kHz to 80 kHz, the position of the respirable dust particles reaching the node is shortened from 47 cm to 1.4 cm, and the distance between the nodes is gradually shortened. When the frequency reaches 100 kHz, the position of the respirable dust particles reaching the node increases to 14 cm. At 80 kHz, the movement distance between respirable dust particles is the smallest, and the distribution of respirable dust particles near 100 μm large particles becomes denser, and the collision probability may be higher. When the particle size of the respirable dust particles increases from 1 μm to 10 μm, the position of the respirable dust particles reaching the wave node increases from 0.1 cm to 5.8 cm.When 1 μm, the movement distance between the respirable dust particles is the smallest, and the distribution of the respirable dust particles near the 100 μm large particles becomes denser, and the collision probability may be higher. The experimental results show that when the frequency is 80 kHz, with the increase of sound pressure level, the agglomeration efficiency of respirable dust particles with 0.7～5 μm particle size is significantly higher than that of other particle sizes, and the agglomeration effect is the best at 125 dB. When the sound pressure level is 125 dB, with the increase of frequency, the agglomeration efficiency of respirable dust particles increases first and then decreases. The agglomeration efficiency of 1 μm respirable dust particles was 33.64%, 36.78%, 40.64% and 38.55%, respectively, and the agglomeration effect was the best at 80 kHz. When the sound pressure level is 125 dB, the frequency is 80 kHz and the humidity is 88%, the adjustment wind speed is 1.0, 1.2, 1.4, 1.6 m/s, and the agglomeration efficiency of 1 μm respirable dust particles is 40.64%, 40.13%, 39.61%, 39.10%, respectively. When the humidity was adjusted to 73%, 78%, 83% and 88%, the agglomeration efficiency of 1 μm respirable dust particles was 37.96%, 38.84%, 39.73% and 40.64%, respectively.