Abstract: Mine safety is the cornerstone of sustainable mining development and an important manifestation of the holistic approach to national security in the field of resource exploitation. However, conventional mine safety theories and technological frameworks have long been confined to sudden catastrophic accidents occurring during the production process, while neglecting long-term and chronic occupational health risks as well as ecological and environmental security in mining areas, which is difficult to meet the safety requirements for deep, intelligent, and green mining development. Against this background, this study systematically reviews existing research and proposes the holistic safety concept to redefine the connotation of mine safety. Mine safety is thereby expanded into a new integrated paradigm consisting of mine production safety, mine production environment safety (occupational health), and mine ecological security. This paradigm shift transforms the object of mine safety from a sole focus on miners to an integrated “human-production environment-ecological environment” system, extends the temporal scale from the production stage to the entire mine life cycle, and broadens the spatial scope from within the mining area to the surrounding ecological impact domain. On this basis, the theoretical framework of three major mine safety scenarios-namely production activities, production environment, and ecological environment-are reconstructed and the interrelationships among various safety scenarios are clarified. Furthermore, a "three-horizontal, three-vertical, one-platform" mining safety technology system covering three major mining safety scenarios, categorized into three technical functions: prevention and mitigation, monitoring and control, and restoration and emergency response is established and an integrated solution for the intelligent mining safety collaborative management platform is developed. The reconstructed mine safety theory and technological framework under the holistic safety concept can systematically address risk challenges throughout the entire life cycle of mining activities, supporting the paradigm transition of mine safety from passive prevention and control to proactive governance, and from a single-dimensional perspective to multidimensional coupling. This framework is of significant scientific importance and engineering application value for promoting the green, intelligent, safe, and sustainable development of the mining industry.