Abstract: The interference of reservoir parameters during the multi-gas and multi-layer combined production of coal measure reservoirs seriously affect the efficient output of coal measure gas. In order to reveal the dynamic change laws and inter-relation of stress, reservoir pressure and fluid production during the multi-gas and multi-layered production process in coal measure reservoirs, a large-scale composite reservoir physical model (1 200 mm×1 200 mm×2 060 mm) containing two sandstone layers and two coal seams is innovatively designed based on the geological conditions of Linxing Block in Ordos Basin. A combined mining experiment of multi-gas and multi-layer in coal measure reservoirs was conducted utilizing the independently developed multi-functional physical simulation experimental system for deep coal and rock engineering. The dynamic gas production patterns of different production layers and interlayer flow interference among them were discussed, and the characteristics of stress transmission and reservoir pressure as well as their impact on adjacent layers were analyzed during the process of gas injection and gas extraction. The results show that during the combined production, the instantaneous gas production peaked and then decreased exponentially, with faster flow decay in sandstone layers during high-flow stages and in coal seams during low-flow stages. During the entire gas production stage, the instantaneous gas production rates of the four layers were observed to be higher in the sandstone layers than in the coal layers, and higher in the thick coal layers than in the thin coal layers. Increasing the flow rate of the sandstone layer would result in a decrease in the flow rate of the coal layer; while reducing the flow rate of the sandstone layer will cause an increase in the flow rate of the coal layer. This indicated that there was a significant inter-layer flow interference among the various production layers. During the combined production process, the decline in reservoir pressure and the rate of pressure decay in thick coal seam is lower than that in thin coal seam. Furthermore, when gas is injected into the sandstone layer, both the solid pressure of the sandstone layer and that of the coal layer will increase. Moreover, during the loading and unloading process, changes in the stress will significantly affect the variation of gas pressure. The research has revealed the interdependent relationships among stress, reservoir pressure and gas production volume during the multi-layered combined production of coal measure gas. It has significant implications for the dynamic regulation of flow rate, cross-layer stress and pressure transmission, as well as the coordinated control of inter-layer interference in the process of multi-layered combined production of coal measure gas.