Abstract: The protection of floor aquifer structure is a key strategy for achieving coordinated development between coal resource exploitation and regional hydrological environments. As a new coal pillarless mining technology, it is of great significance to explore the distribution law of floor four zones in 110 mining method above confined water for evaluating the efficiency of water preservation mining. First, the load function of floor failure zone is established considering the time-effectiveness change of gangue bulking in gob. The implicit equation of the maximum failure depth is constructed based on the Mohr-Coulomb yield criterion, and the sensitivity curve of key influencing factors is analyzed by variable control method. Subsequently, to study the characteristics of confined water lifting zone, a similar simulation test system for the 110 mining method above confined water is developed. This includes a “spring-water bag” integrated device designed to simulate strata and confined water, pre-embedded uplifting soft tubes and branch pipes to simulate prefabricated water-conducting channels, miniature roof-cutting and entry-retaining supports to simulate key processes. The lifting velocity and accumulated flow rate at different positions are obtained by test. Additionally, a FLAC-PFC^3D coupling numerical model with calibrated micro-parameters is established to characterize rock damage by fracture initiation, and the characteristics of floor damage zone are obtained. The mechanical model and similar simulation results are verified by PFC particle displacement and fracture evolution at the top of aquifer, respectively. Finally, the complete floor four zones distribution is obtained by coupled cloud map superposition of floor displacement, damage fracture and confined water lifting. To further verify the division results, the maximum failure depth is measured using floor borehole DC resistivity methods, and the absolute value cloud maps of apparent resistivity changes at 1−3 times the distance are used for visualization; the primary and secondary lifting detection of the Ordovician confined water is carried out by combining directional drilling with conventional secondary drilling. The study shows that the division of the four floor zones in the 110 mining method above confined water is reasonable, and the structural integrity of aquifer is well-maintained. At the same time, the evaluation of water preservation effect first delineates the distribution location and range of microseismic events at different layers from the perspective of frequency and energy, and defines the damage range and characteristics. After that, the change rate of water inflow in the working face is analyzed. The Fisher discriminant analysis is conducted on the water inflow source and the Piper three-line graph of the mine water is drawn. It is found that the water inflow is at the expected level and there are no characteristic ions of Ordovician limestone water in the water source. The research results comprehensively verified the water preservation effect of the 110 mining method above confined mining is good, and realized the dynamic balance between coal seam mining and aquifer structure preservation.