Abstract: In terms of the none intrinsic safety problem of conventional ultrasonic equipment,a novel intrinsic safety ul- trasonic driving system is proposed based on the integration of Buck-Boost converter output and multiplexing high volt- age switching circuit. The intrinsic safety property of the system is analyzed with the calculation of minimum ignition energy of the energy storage component of driving circuit. Also,the intrinsic safety component parameters of Buck- Boost circuit is studied. The design of the circuit structure is applied according to intrinsic safety requirements,inclu- ding the power supply unit,boosting unit,switching unit and controlling unit. In addition,the ultrasonic driving experi- ment is carried out to verify the actual driving effect and the comparison with the conventional intermediate-frequency transformer driving system is also applied. The results show that two driving systems can achieve the similar effect while the driving voltage varies from 16 to 36 V,and the absolute voltage error is within the range of 4 mV by means of the signal detection of two driving systems with the sensitive probe. Thus,the intrinsic safety requirements can be satisfied by this novel driving system based on the Buck-Boost circuit,which is of significance to different ultrasonic equipment in dangerous environment.