Abstract: In view of the shortcomings of traditional alkali solution in the process of hydrogen sulfide treatment,which has low absorption rate and is easy to exceed the limit twice,the surfactant (AE9C-Na) and oxidant (H2O2 ) were selected as the base material to modify the alkali solution. Taking the content of sodium carbonate,surfactant and oxidant as the influencing factors and the removal rate of hydrogen sulfide as the response value,firstly,the influence of the change of the influencing factors on the response value was investigated by single factor experiment,and the influence of different concentrations of surfactant and oxidant in sodium carbonate solution on the removal of hydrogen sulfide was studied. Then,according to the central combination design,the experiment was arranged. According to the test results,the fitting and regression analysis were carried out to get the regression fitting equation. Also,RSM was used to further determine the interaction of the influencing factors. The results showed that the significance order of the influencing factors was:sodium carbonate solution concentration>surfactant concentration>oxidant concentration. The interaction of sodium carbonate solution concentration and surfactant concentration had the greatest impact on the removal rate of hydrogen sulfide. Finally,a design expert software was used to optimize the ratio of modified lye. After considering the absorption efficiency and cost,the optimal percentages for the modified lye developed in this experiment are as follows:the concentration of sodium carbonate solution is 2. 5% ,the concentration of surfactant is 0. 25% ,and the concentration of oxidant is 0. 8% . Taking the 2303 working face of Cui Jiagou coal mine as the test site,the modified alkali solution was sprayed to treat the hydrogen sulfide on site. The field test results showed that the average removal rate of the modified alkali solution for hydrogen sulfide was 90. 3% ,and there was no hydrogen sulfide overrun and secondary escape,so the treatment effect was significant.