Abstract: Mine ventilation system is the respiratory system of mine,its task is to continuously deliver fresh air from ground to every workplace underground,and dilute and eliminate all kinds of poisonous and harmful gases and mineral dust underground. Mine ventilation is the main technical means to prevent coal and gas blast,and provide cooling,de- dusting and fire-fighting. Mine ventilation can ensure the physical and mental health of underground workers and well operation of equipment. Intelligent mine ventilation is also the main technical guarantee for intelligent mining and smart mine construction. Intelligent ventilation is not only related to spatial science,mining technology and hydrody- namics theory,it also needs the support of mathematics,automation,computer and information science. Due to the lack of perfect theoretical and technical support,for a long time,mine ventilation operation has remained in manual and semi manual state. This paper starts with the topological structure and state equation of ventilation network,and discus- ses some theoretical problems such as the algorithm of natural flow distribution,the calculation of flow distribution on demand and the optimization of resistance regulation in detail. Also,some key technologies are investigated such as the optimization of air regulation on demand,pressure equalizing regulation,optimization of airflow direction regulation,op- timization integrated regulation,real time closed loop control,optimized layout of monitoring points,ventilation system state estimation,early prediction of air demand,identification of reverse branch,reliability regulation optimization,ven- tilation system status initialization,ventilation system fault diagnosis,intelligent control air door and window,and intel- lectualized software system. With respect to such problems,this paper gives a complete solutions. These schemes are perfect in theory,technically feasible and can be put into practice. Lastly,to take computer software technology as the main line,the authors have designed a four tier architecture,defined the technical connotation and main function mod- ules of each layer,and illustrated the application prospect. It lays the foundation for building the whole intelligent mine ventilation system.